Logo of Phnom Penh Post newspaper Phnom Penh Post - Gene-edited baby trial ‘paused’




Gene-edited baby trial ‘paused’

Content image - Phnom Penh Post
Chinese scientist He Jiankui claims to have created the world’s first genetically edited babies. ANTHONY WALLACE/AFP

Gene-edited baby trial ‘paused’

The Chinese scientist who claims to have created the world’s first genetically-edited babies said on Wednesday the trial had been paused, following an international outcry over the highly controversial procedure.

He Jiankui defended his work in front of a packed Hong Kong biomedical conference, saying he had successfully altered the DNA of twin girls born to an HIV-positive father, an apparent medical first.

A total of eight volunteer couples – HIV-positive fathers and HIV-negative mothers – had signed up to the trial, with one dropping out before it was halted.

He said there had been “another potential pregnancy” involving a second couple, but when questioned further agreed it had been a chemical pregnancy – a term referring to a very early miscarriage.

“I must apologise this result was leaked unexpectedly,” He said of the apparent breakthrough “the clinical trial was paused due to the current situation,” he added.

The conference has been upended by the gene-edited baby revelations claims, after university professor He posted a video claiming the twin girls – born a few weeks ago – had had their DNA altered to prevent them from contracting HIV.

The move prompted a heated debate among the scientific community, with many raising concerns over the lack of verified data and the risks of exposing healthy embryos to gene editing.

Editing human embryos can create unintended mutations in other areas – so-called “off-target effects” – which can be carried through to birth, experts warned.

But He took to the stage on Wednesday to justify his work and was bombarded with questions as he told the audience that the parents were aware of the potential dangers when they signed up.

“The volunteers were informed of the risk posed by the existence of one potential off-target and they decided to implant,” he said.

He also said the university where he works had been “unaware of the study’s conduct.”

Southern University of Science and Technology, in the southern Chinese city of Shenzhen, had earlier distanced itself from He, saying he had been on unpaid leave since February and had “seriously violated academic ethics and codes of conduct”.

Organisers of the Second International Summit on Human Genome Editing, which opened on Tuesday, also said they had been unaware of He’s work.

Conference moderator Robin Lovell-Badge said He’s trial was a “backward step” for the science industry, but described the babies’ birth as “momentous” nonetheless.

“This is an example of an approach that was not sufficiently careful and cautious and proportionate,” he said.

“Clearly however it is a point in history . . . These two babies would appear to be the first gene-edited babies. So it is a momentous point in history.”

Summit chair David Baltimore, a Nobel laureate, said there had been “a failure of self-regulation by the scientific community because of a lack of transparency.”

He’s claim would “be considered irresponsible”, Baltimore said.

He said the twins’ DNA was modified using CRISPR, a technique which allows scientists to remove and replace a strand with pinpoint precision.

Gene editing is a potential fix for heritable diseases but it is extremely controversial because the changes would be passed down to future generations and could eventually affect the entire gene pool.

In many countries the editing of human DNA is tightly controlled.

Bypassed ethical process

Qiu Renzong, formerly the vice president of the Chinese Ministry of Health’s ethics committee, told reporters at the conference that lax regulations in China mean that scientists who break the rules often face no punishment and think of the ministry as being “without teeth”.

China’s National Health Commission ordered an “immediate investigation” into the case, the official Xinhua news agency reported, while the Shenzhen hospital meant to have approved the research programme denied its involvement.

A union of Chinese scientists issued a statement saying it “resolutely opposes so-called scientific researches and biotech applications that violate the spirit of science and ethics,” Xinhua said.

The case has damaged China’s international reputation in the field, said the Chinese Union of Life Science Societies.

MOST VIEWED

  • Tourists urged not to skip trip

    The Ministry of Tourism has called on international tourists not to cancel trips to Cambodia, but urged them to adhere to several dos and don’ts when arriving in the Kingdom during the Covid-19 pandemic. The ministry released an eight-point instruction manual on Wednesday published

  • The taxman cometh – Cambodia’s capital gains tax casts the net on individual taxpayers

    In a country where only limited personal income tax existed, the new taxation law beginning January 1, 2021, will make taxpayers out of Cambodians, whether they are ready for it or not About two years ago, a little known amendment was made to Article 7 of the Law

  • Cambodian-American gets Star Trek treatment

    Kevin Ung, a Cambodian-American whose family escaped genocide during the Khmer Rouge’s reign of terror, was recently selected from thousands of applicants to participate in the Television Academy Foundation’s inaugural 2020 Star Trek Command Training Programme, a course intended to give hands-on filmmaking experience

  • Cambodia seeks to be transport hub

    Cambodia is working on several fronts to modernise its transport infrastructure and services, concentrating on opening new international gates to relieve and balance traffic congestion at its borders, Minister of Public Works and Transport Sun Chanthol said on Thursday. This is part of the Kingdom’

  • Deminers unearth ancient lion statue

    Cambodia Mine Action Centre (CMAC) director-general Heng Ratana told The Post on Tuesday that a statue of a lion was found by mine clearance experts while they were digging for a development project. It was sent to the Ministry of Culture and Fine Arts last

  • PM: West unfair to Cambodia

    Prime Minister Hun Sen released a message celebrating the International Day of Peace on Monday, saying that some major powers and western countries had been systemically cooperating to put political pressure on Cambodia as they did in the 1970s and 1980s. Hun Sen said pressuring