The Ratanakkiri Provincial Administration has shut 10 locations in O'Yadav district as they were frequented by a man who has tested positive for Covid-19.
In a public notice, provincial governor Thong Savun said the temporary closures were intended to prevent the virus spreading.
The man, 37, was confirmed positive through a rapid test on May 11.
"The district administration must cordon off the locations, ban entry and exit and begin contact tracing to bring those exposed to Covid-19 for quarantine and specimen collection," he said in the notice.
Of the 10 shuttered locations, five are in Pate commune's Plong village and the others in Lumchor commune's Un village.
The provincial administration urged those who had been exposed to the virus at the locations to come forward for testing and self-quarantine.
Ratanakkiri reported its first cases of Covid-19 on May 9, when two men were confirmed positive through rapid testing kits.