Liverpool are badly in need of a Champions League lift to save their season, but with Jurgen Klopp’s men seemingly devoid of confidence and showing signs of physical and mental fatigue, RB Leipzig are far from perfect opponents in the last 16.

Barred from entering Germany due to coronavirus restrictions, the English champions head to Budapest for Tuesday’s first leg on the back of three wins in their last 12 games in all competitions.

That run has ended their chances of silverware by retaining their league title or lifting the FA Cup, leaving the Champions League as Liverpool’s only route to glory this season.

However, there is little reason to believe there is a revival on the horizon for a squad that has been hamstrung by injuries all season and badly in need of rejuvenation.

The loss of three centre-backs – the talismanic Virgil van Dijk, Joe Gomez and Joel Matip – to season-ending injuries has had a devastating impact on Liverpool’s season.

Without them, Liverpool’s bite to quickly recoup possession in midfield has gone as has the pace of Van Dijk and Gomez to defend a high line.

The injuries have also meant the core of Alisson, Trent Alexander-Arnold, Andy Robertson, Henderson, Fabinho, Georginio Wijnaldum, Sadio Mane, Roberto Firmino and Mohamed Salah have had to carry a huge burden of minutes in a season congested like no other.

After four years of implementing Klopp’s energy-sapping style of high pressing football, Liverpool’s reserves have run dry.

“When you look at the percentage of Premier League minutes played from August 2018, this is a team that have gone to the well for three years and produced unbelievable moments, trophies for this club,” former Liverpool defender Jamie Carragher told Sky Sports.

“This is not an attitude thing. This is not a team who think, ‘We’ve won the league, we’ve made it’. They just haven’t stopped for three years.”

Carragher pointed to the transformational impact the three signings of Salah, Van Dijk and Alisson had in consecutive transfer windows in 2017 and 2018 to turn Liverpool into champions.

With Salah and Mane turning 29 this year and Firmino 30 in October, the chance to cash in on another prize asset in their peak looks to have gone.

Leipzig’s controversial ownership structure as part of Red Bull’s sports empire may not be popular with fans in Germany, but it has helped them become a model for successful player trading.

Dayot Upamecano’s departure to Bayern Munich at the end of the season for €43 million is the latest big profit to be made on a player signed for just €2 million by another Red Bull-owned club Salzburg five-and-a-half years ago.

Despite losing the goals of another long-term Liverpool target Timo Werner to Chelsea, Leipzig are Bayern’s closest challengers for the Bundesliga this season and knocked out Manchester United to reach the last 16 from a competitive group, also including Paris Saint-Germain.

A steady stream of young new recruits such as Dani Olmo, Christopher Nkunku, Konate and Angelino, has made Leipzig a real force on the European stage and gave a lesson for Liverpool in how not to allow standards to slip with a stale squad.