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Novavax gets $1.6 billion for vaccine against Covid

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Dr. Nita Patel, Novavax director of antibody discovery and vaccine development, examines a vial of the company's experimental COVID-19 vaccine. AFP Photo/ANDREW CABALLERO-REYNOLDS

Novavax gets $1.6 billion for vaccine against Covid

The US on Tuesday announced that it will provide $1.6 billion in funding for the development and manufacture of a Covid-19 vaccine candidate produced by biotech firm Novavax Inc, the largest amount awarded under Operation Warp Speed.

Separately, the US also said it will provide $450 million to Regeneron Pharmaceuticals Inc for its experimental Covid-19 treatment and prophylaxis, a combination of two antibodies.

Under the terms of its agreement with the Department of Health and Human Services (HHS) and Department of Defence, Novavax agrees to deliver 100 million doses of its vaccine, potentially by the end of the year.

The company’s president and CEO Stanley Erck said: “We are honoured to partner with Operation Warp Speed to move our vaccine candidate forward with extraordinary urgency in the quest to provide vital protection to our nation’s population.”

The final stage Phase III trial of its vaccine, called NVX-CoV2373, is set to take place in autumn.

The Maryland-based company uses insect cells to grow synthesised pieces of the Sars-CoV-2’s “spike protein”, which the virus uses to invade cells, in order to trigger the human body’s immune response.

It also uses an “adjuvant”, a compound that boosts the production of neutralising antibodies.

In the spring, the company said it had proven the efficacy of a seasonal flu vaccine it had developed using similar technology.

The amount awarded to Novavax by the US is higher than the $1.2 billion given to the Oxford University vaccine that is being developed by British-Swedish multinational pharmaceutical firm AstraZeneca Plc.

Under Operation Warp Speed, the US is aiming to deliver millions of doses of safe and effective vaccines for Covid-19 next year.

Also on Tuesday, the US said it was providing New York-state based Regeneron with $450 million to scale up manufacture of its Covid-19 antibody treatment.

The company, which announced on Monday it was entering late-stage human trials, estimates that it could have between 70,000 and 300,000 treatment doses, with the first available by late summer.

The drug, called REGN-COV2, is a combination of two antibodies that block the coronavirus’ spike protein.

Regeneron scientists evaluated thousands of antibodies harvested from genetically-modified mice with human immune systems and from humans, identifying the two they found to be most potent, while not competing against each other.

The company uses a multi-antibody strategy to decrease the chances that the virus will mutate in order to evade the blocking action of a single antibody, an approach it detailed in a recent study in Science.

Last year, a triple antibody cocktail developed by Regeneron was shown to be effective against the Ebola virus.

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